Molecular mechanisms of inflammation in the pathogenesis of respiratory disorders in patients with pulmonary tuberculosis

Aim. To assess external respiration (ER) and its relationship with the activity of enzymes involved in purine metabolism patients acute chronic forms pulmonary tuberculosis (TB). Materials methods. In TB, we assessed adenosine deaminase (ADA)-1, 2 blood serum (eADA), mononuclear cells, neutrophils, concentration ecto-5’-nucleotidase (eNT5E) serum, level CD26 (dipeptidyl peptidase-4, DPPIV) production reactive oxygen intermediates (ROI) nitrogen (RNI) cells as well parameters ER. Results. Patients TB were found to have an increase eNT5E eADA-2 stimulated ROI a decrease DPPIV (CD26) fall RNI neutrophils. ADA-1 noted. eADA-1 reduced spontaneous neutrophils revealed. Correlations between ER Conclusion. The data obtained make it possible associate regulation metabolism, particular responsible for generation adenosine, that determine outside inside expression cofactor molecules, duration activation innate immunity, monocytes/ macrophages, determined largely by potential regulation.